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Cytochalasin H

CAS No. 53760-19-3

Cytochalasin H ( (16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl) acetate )

产品货号. M24524 CAS No. 53760-19-3

Cytochalasin H 是肌动蛋白掺入肌丝的有效抑制剂。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥3216 有现货
10MG ¥4836 有现货
25MG ¥7881 有现货
50MG ¥10449 有现货
100MG ¥14337 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Cytochalasin H
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Cytochalasin H 是肌动蛋白掺入肌丝的有效抑制剂。
  • 产品描述
    Cytochalasin H is a potent inhibitor of actin incorporation into filaments.
  • 体外实验
    Apoptosis AnalysisCell Line:A549 cells Concentration:0, 6.25, 12.5, 25 and 50 μM Incubation Time:48 h Result:Induced apoptosis in a dose-dependent manner in the A549 cells.Cell Cycle Analysis Cell Line:A549 cells Concentration: 0, 6.25, 12.5, 25 and 50 μM Incubation Time:48 h Result:Arrested cell cycle at the G2/M phase and sub-G1 peaks.Western Blot Analysis Cell Line:A549 cells Concentration:0, 6.25, 12.5, 25 and 50 μM Incubation Time:48 h Result:Increased the protein expression levels of Bax, P53 and cleaved caspase-3 and decreased the protein expression levels of Bcl-xL, Bcl-2 and full-length caspase-3.
  • 体内实验
    Animal Model:male Balb/cnu/nu mice with A549 xenograftDosage:2.5 mg/kg Administration:intraperitoneal injection; 3 injections/week,for 80 days Result:Attenuated tumor growth in vivo.
  • 同义词
    (16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl) acetate
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    ET-1|MMP2
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    53760-19-3
  • 分子量
    493.63
  • 分子式
    C30H39NO5
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    C[C@@H]([C@@H]([C@H](Cc1ccccc1)N1)[C@@]([C@H]([C@@H]2O)/C=C/C[C@H](C)C[C@](C)(/C=C3)O)([C@@H]3OC(C)=O)C1=O)C2=C
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Ma Y , Xiu Z , Zhou Z , et al. Cytochalasin H Inhibits Angiogenesis via the Suppression of HIF-1α Protein Accumulation and VEGF Expression through PI3K/AKT/P70S6K and ERK1/2 Signaling Pathways in Non-Small Cell Lung Cancer Cells[J]. Journal of Cancer, 2019, 10(9).
产品手册
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